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[34] [35] Eastern Asians reportedly have a deficiency in acetaldehyde metabolism in a surprisingly high percentage (approaching 50%) of their populations

Fleming, A., Noda, T., Yoshimori, T

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Patients with severe MTHFR deficiency (0-20% residual enzyme activity) in infancy or adolescence present with developmental delay, severe mental retardation, motor and gait dysfunction, seizures, psychiatric disturbances, and other neurological abnormalities

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